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The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotoninExamples include street drugs such as MDMAecstasyStJohn’s wortdextromethorphancertain antidepressantsincluding SSRIs such as fluoxetine/paroxetineSNRIs such as duloxetine/venlafaxineTCAs such as amitriptyline/doxepincertain narcotic medicationssuch as meperidinemethadonepentazocinepropoxyphenetramadoltapentadolamong othersThe risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Because of the risk of confusionhypomaniahallucination and manic episodesagitationmyoclonushyperreflexiaincoordinationshiveringtremorconvulsionataxiadiaphoresisdiarrheafeverhypertensionwhich can be part of the serotonine syndromeconcomitant administration of selegiline and SSRIs or SNRIs is contraindicated.

Eldepryl is contra-indicated in patients with known hypersensitivityincluding severe dizziness or hypotensionto selegiline or any of the excipients listed in section 6.1.

Before having surgerytell your doctor or dentist you are taking this medicationYou may need to stop taking this drug beforehandFollow your doctor’s instructions carefully.

You may have increased sexual urgesunusual urges to gambleor other intense urges while taking this medicationTalk with your doctor if you believe you have any intense or unusual urges while taking Eldepryl.

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